View all research projects
Research project

Bioengineering to combat the tuberculosis pandemic

Project overview

We will combine engineering and biological approaches to investigate the host-pathogen interaction and identify new therapeutic targets.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

  • tuberculosis
  • immunopathology
  • diagnosis
Connect with Paul

Email: P.Elkington@soton.ac.uk

Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Professor of Bioengineering

Research interests

  • Microfluidics and Lab-on-a-Chip Technologies
  • Biomedical and Chemical Engineering
  • Nanomaterials
Connect with Xunli

Email: XL.Zhang@soton.ac.uk

Research outputs

Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α
Liku B. Tezera, Magdalena K Bielecka, Paul Ogongo, Naomi F. Walker, Matthew Ellis, Diana J. Garay-Baquero, Kristian Thomas, Michaela T. Reichmann, David A. Johnston, Katalin Andrea Wilkinson, Mohamed Ahmed, Sanjay Jogai, Suwan N. Jayasinghe, Robert J. Wilkinson, Salah Mansour, Gareth J. Thomas, Christian H. Ottensmeier, Alasdair Leslie & Paul T. Elkington, 2020, eLife, 9
DOI: 10.7554/eLife.52668
Type: article
Reconsidering the optimal immune response to Mycobacterium tuberculosis
Liku Bekele Tezera, Salah Mansour & Paul Elkington, 2019, American Journal of Respiratory and Critical Care Medicine, 201(4)
DOI: 10.1164/rccm.201908-1506PP
Type: review
In vitro granuloma models of tuberculosis
Paul Elkington, Maria Lerm, Nidhi Kapoor, Robert Mahon, Elsje Pienaar, Dongeun Huh, Deepak Kaushal & Larry Schlesinger, 2019, Journal of Infectious Diseases, 219(12), 1858–1866
DOI: 10.1093/infdis/jiz020
Type: review
Implications of tuberculosis reactivation after immune checkpoint inhibition
Paul Elkington, Adrian Bateman, Gareth Thomas & Christian Ottensmeier, 2018, American Journal of Respiratory and Critical Care Medicine, 198(11), 1451-1453
DOI: 10.1164/rccm.201807-1250LE
Type: letterEditorial
Advanced cellular systems to study tuberculosis treatment
Magdalena K. Bielecka & Paul Elkington, 2018, Current Opinion in Pharmacology, 42, 16-21
DOI: 10.1016/j.coph.2018.06.005
Type: article